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Ischemic models induce rapid oxidative damage by reperfusion-induced ROS, allowing detailed investigations into acute oxidative injury mechanisms, tissue-specific antioxidant responses, and therapeutic efficacy of antioxidants and regenerative interventions such as stem cell-derived EVs (Table 1)

Furthermore, this combination strategy has been evidently demonstrated through recent pivotal clinical trials, granted approval from FDA, and is now being used in patients with kidney, liver, lung, or uterine cancer