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A cross-sectional analysis found that MeDi adherence was associated with increased gut microbial diversity and higher levels of short-chain fatty acids, metabolites linked to reduced inflammation and improved vascular health (De Filippis et al., 2016)

notably, SFN suppresses the NF-B pathway, reducing pro-inflammatory cytokine production that otherwise supports tumor growth and immune evasion (121)

Paine SM, Anderson G, Bedford K, Lawler K, Mayer RJ, Lowe J, Bedford L (2013) Pale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of -synuclein