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1 Methylation is critical to a multitude of metabolic processes including: Cell division, DNA and RNA synthesis Detoxification and hormone biotransformation Neurotransmitter biosynthesis CNS development and neural tube formation Histamine clearance Phospholipid synthesis Myelination of peripheral nerves Methylation and Nutrient Status Particular attention has been focused on folate and MTHFR and other potential gene variants that influence folate metabolism and methylation

Consistent with these metabolite levels, a HF-SAAR diet prompted a rise in the 13 C-labeling of liver serine and glycine in WT mice intravenously infused with [U- 13 C]glucose (Fig

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