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Alpha lipoic acid (LA) Alpha lipoic acid (LA) is part of the multienzyme complex of pyruvate dehydrogenase, alpha-ketoglutarate and branched alpha-keto acids [58, 59]

Western Blot Analysis Proteins were extracted from tissues and cells using a Nuclear and Cytoplasmic Protein Extraction Kit (Beyotime)

Excess ROS then activates the NLRP3 inflammasome in microglia, promoting maturation and release of IL-1 ( 4.3 GSH metabolism: a central hub in mid-late SAE The hippocampus, with its high metabolic demands and low antioxidant capacity, is uniquely vulnerable to septic injury ( A Stat1-Gpx3 hub was identified, where TNF-/IL-1-induced Stat1 activation suppresses Nrf2 (confirmed by reduced hippocampal Nrf2)

Known as the body's master antioxidant, glutathione plays a vital role in detoxification, immune function, and skin brightening