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In models, moderate ROS levels in HepG2 and Huh7 cells activate ERK and AKT, leading to the transcriptional induction of mesenchymal markers (Snail, vimentin) and matrix metalloproteinases (MMP-2/9), while concurrently repressing epithelial E-cadherin [91]

doi: 10.3389/fphar.2022.983623 325 WangCChenSGuoHJiangHLiuHFuHet al

[12] Gastric acid-suppressing agents (proton-pump inhibitors and H-receptor antagonists) diminish dietary B12 liberation from protein complexes, a pharmacodynamic interaction that can exacerbate underlying deficiency