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Thus, although changes in lipid composition can have a significant impact in membrane physical properties, which in turn affect mitochondrial function, the cumulative evidence points to a crucial role for cholesterol accumulation in orchestrating these deleterious effects in mitochondria via impaired antioxidant defense and subsequent ROS generation, affecting essential unique lipid components like CL

NMR spectroscopy measurements NMR spectra were recorded on a Varian 600 MHz spectrometer at 25.0 0.1 C

Sleep: 2-3 weeks

A firstinhuman, randomized, doubleblind, single and multipledose, phase I study of recombinant human thymosin 4 in healthy Chinese volunteers