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In AD, the abnormal aggregation of amyloid-beta (A) protein contributes to increased oxidative stress, which is believed to play a central role in disease onset

This mainly occurs in immunocompromised people or people with chronic lung conditions.[ref][ref] Aspergillus infection in the lungs or respiratory tract secretes aflatoxins

The lumen formed around the endoderm is the original intestinal lumen, and the endoderm is the main cell source for the development of the internal organs (Wells and Melton, 1999)