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Cells were then counted using an automated cell counter (Entek) and transferred in 200 l 1 PBS or ultrapure water to the cleaned glass vials

14 Through cytokine signaling, direct cell-cell interactions, and metabolic crosstalk, CLL cells establish a protective niche that enhances their survival by, among other things, adapting their metabolism, increasing their antioxidant capacity, and mitigating oxidative stress