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Quercetin can reduce the activity of NADPH oxidase and vascular superoxide in hypertensive rat models, thereby improving vascular endothelial function and lowering blood pressure ( In a clinical study of quercetin in the treatment of grade 2 hypertension, it was found that quercetin can significantly reduce the levels of nitric oxide, CRP, IL-1, and lipid profile in patients' peripheral blood ( Another randomized, double-blind, crossover clinical study found that 41 hypertensive patients had a significant decrease in blood pressure after 28 days of continuous administration of 730 mg quercetin, while the measured oxidative stress index in plasma and urine remained unchanged, which was contrary to previous animal experimental studies (130)