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Following various treatments, the MTT reagent was added and incubated for 4 h, after which the formazan crystals were solubilized and absorbance was measured at 570 nm using a microplate reader [36]

Keywords: quinolone antibiotics, disease treatment, SOS response, lethality, bacteria Introduction The earliest quinolone antibiotics were discovered in the 1960s

Dosing protocols Phase 2 clinical trials used a titration schedule starting at 0.5mg weekly, escalating through 1mg, 2mg, 4mg, 8mg, and reaching maintenance doses of up to 12mg weekly over several months

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