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The lack of efficacy of inhaled GSH in patients with cystic fibrosis could be explained by the high concentrations of the GSH-degrading enzyme -glutamyltransferase present in lung fluids of those patients (116123), and then, the use of precursors of GSH synthesis like NAC and cystine could be more effective in the synthesis of GSH (124)

PPP A study using metabolic tracing revealed that the 13 C-labeled glucose is more likely to enter the PPP pathway under high glucose stimulation [115]

Insight Nanotechnol 1: 15222

Different CRN architectures, including pH-responsive polymeric micelles, lipid-based nanoparticles, and dendrimer-based systems, have demonstrated improved tumour penetration and minimised systemic toxicity in murine and xenograft models