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Antioxidant enzymes such as superoxide dismutase 1 (SOD1), and glucose6phosphate dehydrogenase (G6PD) decrease from HMRD-induced oxidative stress (OxS) and protein degradation 50,51

Integrated Research Applications AOD9604 started as a fat metabolism compound but has since opened up a second research direction in joint and cartilage biology: The bulk of AOD9604 research sits here

As observed with ML385, AA147 did not improve viability in glutamate-treated HT22 cells shRNA depleted of Nrf2 , further indicating that AA147-dependent NRF2 activation is required for protection against glutamate toxicity ( Fig