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Meynier S, Rieux-Laucat F

10.1007/s00401-017-1704-z Acta Neuropathol

In addition to decreasing homocysteine levels, which could potentially help reduce the risk of heart disease, some research also indicates that higher vitamin B12 levels may be linked to improved outcomes for those who have suffered from an ischemic stroke and may be associated with a lower risk of coronary artery disease

A benzimidazole compound, milbefradil, which displays structural homology to benzimidazole NS8593, activated TRPM7-mediated Ca 2+ entry with an EC 50 of 53 M and activated TRPM7 currents at 100 M with a physiological intracellular Mg 2+ concentration (0.9 mM) but failed to activate with a higher [Mg 2+ ] i (1.8 mM), whereas milbefradil failed to activate TRPM3, TRPA1, and TRPV1 channels (Schfer et al., 2016)