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Abstract The rates of cigarette use among American adults have dropped substantially throughout the last six decades, yet smoking remains the leading cause of preventable disease and death in the United States

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Given the extreme risks cigarette smoking poses to the public health, new warnings, as described in detail below and as included in this proposed rule, are critical to promote greater public understanding of the negative health consequences of cigarette smoking

One of the few "near-risk-ties" between the e-cig and patch was in the number of women with adverse birth outcomes, which occurred with 112 or 20.5% of e-cigarette users and 118 or 21.7% of patch users