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The next day, a second blood sample is taken, so that the change in the amount of B12 bound to serum holoTC can be determined

Collectively, oxidative stress, mitochondrial dysfunction, and glutamate excitotoxicity are causing each other forming a neurotoxic vicious cycle (80)

Furthermore, as highlighted in the Future Directions, continued research is necessary to optimize dosing, standardize formulations, and confirm long-term benefits in larger populations