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While some studies suggest that overexpression of IGF-IR or phosphorylated IGF-IR is inversely associated with patient prognosis among all subtypes of breast cancer [36,37,38], another study reveals that IGF-IR is only inversely associated with prognosis in ErbB2-positive breast cancer [39]

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A crucial aspect of the treatment methodology was the method of delivery: intracerebroventricular (ICV) infusion

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