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Pyrimidine derivatives as selective COX-2 inhibitors with anti-inflammatory and antioxidant properties

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(PubMed) Sawicka AK, Hartmane D, Lipinska P, Wojtowicz E, Lysiak-Szydlowska W, Olek RA

A key trial found that 600mg per day provided the best balance of effectiveness and tolerability, reducing instances of nausea, dizziness, and GI discomfort.4 A separate review of multiple studies supports this, concluding that 600mg daily is effective and well-tolerated for conditions like diabetic neuropathy, insulin resistance, and oxidative stress.5 That body of research has established 600mg of racemic ALA as a standard dose in clinical studies, thanks to its consistent balance of efficacy and tolerability