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Our team with clinical studies on Alzheimers patients has shown that iron deposition in the hippocampus along with decrease in the levels of the antioxidant glutathione in the same area of the brain is one of the important factors of the disease, says Dr Pravat Mandal, senior scientist and former director-in-charge of the National Brain Research Centre The recent approval of three drugs to prevent cognitive decline in Alzheimers patients came as a ray of hope for many but could there be other factors at play

In this context, the structure of the NRF2-Keap1 complex may undergo alterations

depleting TAMs reverses this process and enhances the efficacy of immune checkpoint blockade (78)