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These tyrosines create docking sites for a variety of adaptor proteins and direct kinase substrates including the growth factor receptor-bound protein 2 (Grb2), Grb2-associated adaptor protein (Gab1), son of sevenless (SOS), SRC homology protein tyrosine phosphatase 3 (Shp2), phosphatidylinositol-3-kinase (PI3K) and signal transducer and activator of transcription 3 (STAT3)

Dr Qiang Luo from Fudan University said: These findings are very promising and suggest we will be able to use the biomarker measure to identify which children with ASD will benefit most from bumetanide

These findings come predominantly from preclinical or small human studies and have not been confirmed by large-scale controlled investigations

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