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Description

PROTAC-based approaches have been developed to induce selective degradation of enzymes such as DHFR, thereby eliminating both their catalytic and non-catalytic activities and potentially overcoming resistance linked to active-site mutations [188]

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Die wissenschaftliche Gemeinschaft mahnt Vorsicht bei breitflchiger Anwendung auerhalb kontrollierter Studien an

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Best-documented routes: IV (strongest evidence, fastest onset), followed by injectable and liposomal oral

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TPE-MI offers a simple and sensitive method for the detection of thiol, however, with poor selectivity among different thiols

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