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Our laboratory utilizes a developmental toxicant exposure model created by exposing pregnant C57/BL6 mice (F0, or founding generation) to a single 10 g/kg dose of TCDD by oral gavage on embryonic day 15.5 providing in utero and lactational exposures of TCDD to offspring (F1 generation) (Nayyar et al., 2007)

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Andreeff M , Escudier A, Goodacre A, Stilgenbauer S, Engel H, Walker S, Gahn B, Keyhani A, Shi G, Drach J, Zhao S, Liu Y, Rondon G, Jendiroba D, Cabanillas F, Siciliano M, Champlin R, Younes

[15] Hypersensitivity reactions including anaphylaxis or anaphylactoid reactions and allergic skin reactions may occur with tranexamic acid use