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It is associated with increased intestinal permeability and bacterial translocation to the liver and spleen, predominating the effect in the colon [70]

Cell Death Differ 8:10471048 Norbury CJ, Zhivotovsky B (2004) DNA damage-induced apoptosis

In addition, oral administration of KDS12025 (3 mg/kg/day, 2 weeks, drinking ad libitum ) normalized the levels of astrocytic GABA and the oxidative stress marker 8-OHdG in APP/PS1 to wild-type levels (Supplementary Fig

Vitamin E modulates inflammation by interacting with cyclooxygenase (COX) enzymes, which are responsible for the synthesis of prostaglandins at the site of inflammation (Schubert et al