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TMAO reduces synaptic plasticity and induces cognitive dysfunction by promoting endoplasmic reticulum stress and directly binding to activate PERK, which damages synaptic plasticity (Zhang et al., 2007

Disease mechanisms and therapeutic approaches in spinal muscular atrophy

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One enrolled vegan/vegetarian subject was later excluded as a result of reported nausea and a low BMI, 1 omnivorous subject declined the challenge after being enrolled and giving consent, 3 subjects enrolled in the antibiotic suppression arms did not tolerate the antibiotics (gastrointestinal distress) and were thus excluded from the study, and 2 subjects admitting noncompliance with daily l-carnitine supplementation were only included in baseline challenge studies