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16 , 637647.e13 (2018)

Following endogenous growth hormone release, downstream production of insulin-like growth factor-1 (IGF-1) contributes to many of the physiological processes associated with growth hormone biology

Clinicians have reported cases of tramadol-induced mania in patients without a prior history of bipolar disorder (61)

The most common neurological manifestation is subacute combined degeneration of the spinal cord and peripheral sensory neuropathy, while epilepsy is a rare manifestation in cases of vitamin B12 deficiency [84]