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The intense focus on living in the present is an over-arching theme in his posts and interviews

doi: 10.1007/s00383-020-04762-5 164 MokhtariT.AkbariM.MalekF.KashaniI

309 When IgE binds to FcRI to trigger immunity, FcRI aggregation induces a variety of signaling pathways to regulate the secretion of allergy-associated mediators, including histamines and leukotrienes, and induces the transcription of Th2 cytokines and tumor necrosis factor (TNF) genes, 310 which leads to potentially life-threatening allergic diseases