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The therapeutic approach centers on isoform-selective inhibitors or genetic silencing, complemented by pathway co-targets that feed these enzymes (e.g., angiotensin/PKCNOX axes) and precision delivery to the relevant plasma-membrane, endosomal, or nuclear microdomain to avoid off-target suppression of host defense (Cipriano et al

Is it better to combine separate compounds targeting different pathways, or to engineer single molecules that activate multiple receptors simultaneously

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The weight loss itself accounts for some of this effect, but GLP-1 receptor activation also appears to have direct anti-inflammatory and anti-fibrotic effects in liver tissue