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doi: 10.1111/j.1365-3040.2009.01944.x 125 MittlerR

This underscores the need for alternative or adjunctive approaches

This suggests that activation of PXR by some drugs may be responsible for the acceleration of vitamin D breakdown through increasing CYP3A4 and CYP24, leading to vitamin D deficiency and, eventually, to bone loss [1]

It was believed that a malnourished state depleted hepatic GSH and thus reduced the ability to detoxify NAPQI leading to increased risk of toxicity [73, 76]