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The most visible signs of male skin aging are: Deep expression lines forehead, between the brows, around the eyes from decades of facial movement Loss of jaw definition from collagen and elastin decline in the lower face Rough, uneven texture from reduced cell turnover and accumulated UV damage Enlarged pores from years of sebum production and gradual loss of surrounding collagen support Dullness from reduced circulation and decreased cellular energy in aging skin GHK-Cu addresses all of these through its core mechanism stimulating new collagen synthesis, reducing inflammation, activating antioxidant defense systems, and promoting tissue remodeling

It promotes the formation of new blood vessels, which improves nutrient delivery to healing tissues

doi: 10.1016/S0735-1097(03)00575-8

hence it may be a risk factor for humans, especially following long-term exposure (94)