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This phenomenon highlights the importance of the complete peptide for proper enzyme activity ( Figure 2 As per our knowledge, 132 mutations have been reported in MTHFR gene that may cause several disorders such as homocystinuria, anencephaly, tetralogy of Fallot with cleft lip/palate, MTHFR deficiency, acute aortic dissection, reduced enzyme activity, association with preeclampsia, increased erythrocyte folate, respiratory failure and hypotonia, coronary heart disease, Ehlers-Danlos syndrome IV, and Facial palsy ( MTHFR gene has been compiled in Supplementary Table 1

Bladder training involves gradually increasing the time between urinations, helping to reduce bladder overactivity and urgency