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PARP1 intracellular target engagement assay An Echo acoustic liquid handler (Labcyte) was used to transfer compound in a ten-point doseresponse series (100-nl transfers) to empty wells on a white, tissue-culture-treated 384-well plate

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The results show that according to the IUPAC classification of adsorption isotherms [27], the N 2 isotherm resembles the type V with an H1 hysteresis loop, which indicates a mesoporous material with uniform distribution of spherical and cylindrical narrow mesopores