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If the safety and modest efficacy data from the published trials translate to our patient population, it would give us a tool that acts directly on fat cell metabolism rather than appetite, with a side effect profile that appears extremely well-tolerated

These ranges come from allometric scaling of the animal work plus anecdotal reporting not human trials so anchor your expectations to that

2.12.1 Therapeutic investigations BALB/c mice have served as an invaluable model for investigating the therapeutic potential of natural compounds in AD research

Alcohol would not fall under the category of an essential nutrient because not having it in your diet does not lead to any sort of deficiency