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The strategy should specify goals and specific time-bound objectives, the interventions to be implemented vertically (between the national and various subnational levels) and horizontally (across sectors within national and subnational levels), and the mechanisms by which different government and non-government institutions will coordinate efforts in an integrated programme

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References Aggarwal, S., Acharjee, A., Mukherjee, A., Baker, M

The study found that after IDH1 mutation, it will catalyze the massive conversion of 2-KG to tumor metabolite 2-HG, while consuming reduced NADPH