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Weeks 16-52: Final phase The length of isotretinoin treatment varies depending on individual factors like body weight, dosage tolerance, and acne severity

This reasoning was proved experimentally [57]

Moreover, since S -glutathionylation is a reversible process, it has been regarded as a protective mechanism against irreversible P-SH oxidation to sulfinic/sulfonic acids (Schafer et al

Among the potential therapeutic approaches, interventions targeting endothelial dysfunction (such as RAAS modulators, and flavonoids) and persistent inflammation (e.g., antioxidants, vitamin C, vitamin D, and AMPK activators like metformin) appear particularly promising