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Glutathione is broken down in the digestive tract before it can be absorbed into the bloodstream, resulting in minimal increases in cellular levels

-syn aggregation leads to increased iron deposition and ferroptosis in PD mice, while MT1 knockout reduces the resistance of neurons to ferroptosis by inhibiting the SIRT1/Nrf2/HO-1/GPX4 pathway and inhibiting the expression of ferritin FTH1, resulting in more ferrous ion release, which further leads to more DA neuron loss and severe dyskinesia

Jolliffe DA, Ganmaa D, Wejse C, Raqib R, Haq MA, Salahuddin N, Daley PK, Ralph AP, Ziegler TR, Martineau AR

While it can be nothing more than speculation because of the small sample size, patients who showed therapeutic effects following glutathione treatment appeared to be younger and did not have diabetes or had mild diabetes