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52 The melanocortin-1-receptor ( MC1R ) gene regulates human pigmentation and is highly polymorphic in populations of European origin

Biomedicines 2023,11, 2226 7 of 18 4.1

Polycyclic aromatic hydrocarbons (PAHs) found in cigarette smoke, for example, have been shown to decrease the activity of P450 enzymes, leading to a decrease in SAMe production and impaired DNA methylation