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2005 Nov [cited

Finally, an imbalance in GSSG:GSH ratio induces ER stress and dependency on the ER-associated degradation (ERAD) pathway, driven by a shift in protein disulfide isomerases (PDIs) toward their oxidized forms

For instance, factors like high medical expenses or access to good non-HDHP options are typically more likely to disfavor an HSA, as these can reduce the benefits of the plan's high-deductible structure

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