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In addition to CR, inhibiting mTORC1 either by pharmacological treatment, mutations, or low protein, high carbohydrate (LPHC) diets has similar beneficial effects 4,5,6,7,8

BickertTTrujillo-VargasCMDuechsMWohllebenGPolteTHansenGet al

Of significant concern, data published by the FDA conducting the most extensive review of drug-induced ischaemic priapism found that 55.7% were 40 years old or younger with a median age of 36 [4]

Specifically, the CD68-positive area in the aortic root sections of the P-Mn/TI@mHSA group was ~11.59%, which was markedly lower than that observed in the PBS control group (39.44%), as well as the Mn/TI@mHSA (30.95%), P-Mn@mHSA (23.39%), and P-Mn/TI@mHSA-N groups (19.70%) (Fig