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Interaction of the nuclear localizing cytolytic granule serine protease granzyme B with importin alpha or beta: modulation by the serpin inhibitor PI-9

Supplementation with PUFAs and acyl-carnitines warrants further investigation as a potential strategy for the management of MDD

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Disclosures: Taotao Yan: Nothing to Disclose, yuan yang: Nothing to Disclose, Danfeng Ren: Nothing to Disclose, Juan Li: Nothing to Disclose, Qiao Zhang: Nothing to Disclose, Gezhi Zheng: Nothing to Disclose, jinfeng liu: Nothing to Disclose, yingren Zhao: Nothing to Disclose 688 HEMOADSORPTION WITH CONTINUOUS RENAL REPLACEMENT THERAPY REDUCES CATECHOLAMINE REQUIREMENTS AND HYPERCYTOKINEMIA IN ACLF PATIENTS WITH SEPTIC SHOCK AND STAGE 3 AKI- A PROSPECTIVE COHORT STUDY Rakhi Maiwall 1 Fagun Sharma 2 Harsh Vardhan Tevethia 2 Shiv Kumar Sarin 2 , 1 Institute of Liver and Biliary Sciences, 2 Institute of Liver & Biliary Sciences Background: The intensity of systemic inflammation drives organ failures in patients with acute on chronic liver failure (ACLF)