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Additionally, cyclin dependent kinases (CDKs) are also key regulators of DRR, which led to a phase I study examining the combination of ribocliclib, a CDK4/6 inhibitor, with carboplatin/paclitaxel in patients with recurrent platinum-sensitive ovarian cancer (NCT03056833) [85]

While the half-life of Nr1i3 mRNA is approximately 6.6h, the half-life of CAR protein remains unknown and could be investigated in primary hepatocytes in future experiments (75)

The TGA said it has been alerted to severe allergic reactions that have led to hospitalisation, severe inflammation, full-body intense itching, palpitations, pain, insomnia, blurred vision and musculoskeletal injuries

Methods: Retrospective study of patients with cirrhosis and ascites from a single quaternary centre from Apr 2020 to Mar 2021 identified patients who fulfilled the 2015 International Ascites Club (IAC) diagnosis of AKI