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abietic acid, alantolactone ( 16 ), MLN120B, and shikonin, have been used in the treatment of other cancers as well [60, 66, 67]

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Abbreviations A 2535 -amyloid fragment 25-35 EGCG (-)-epigallocatechinegallate L-theanine N -ethyl -L-glutamine FTIR Fourier transform infrared spectroscopy ThT thioflavin T TEM transmission electron microscope MTT 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl tetrazolium bromide ATP adenosine triphosphate ROS reactive oxygen species GAP43 growth associated protein-43 TNF- tumor necrosis factor- BACE1 beta-site amyloid cleaving enzyme-1 A42 amyloid 1-42 IL-6 interleukin-6 NF-kB nuclear factor kappa-B mTOR mammalian target of rapamycin P-mTOR phospho-mammalian target of rapamycin Sirt1 Sirtuin1 UPs ubiquitin conjugated proteins 4-HNE 4-hydroxynonenal RAGE receptor for advanced glycation endproducts p62 sequestosome 1 SASP the senescence-associated secretory phenotype MMP mitochondrial membrane potential LDH lactate dehydrogenase JC-1 it is an ideal fluorescent probe widely used to detect mitochondrial membrane potential DAPI It is a fluorescent dye that can bind strongly to DNA and is often used in fluorescence microscopy TPM trans per kilobase of exon model per million mapped reads BDNF brain-derived neurotrophic factor 50 M A 2535 A 2535 50 M A 2535 /50 M EGCG A 2535 /EGCG 50 M A 2535 /50 M L-theanine A 2535 /L-theanine 50 M A 2535 /50 M EGCG + 50 M L-theanine A 2535 /EGCG + L-theanine

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