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Hu et al (37) observed the morphological characteristics of cuproptosis induced by copper nanoparticles and found significant mitochondrial atrophy, reduction or disappearance of cristae and increased membrane density

Structural modifications to diol type ginsenosides form MRPs that potentiate hydroxyl (OH) radical-scavenging activity of Panax ginseng 629

Under oxidative stress, excessive ROS such as OH directly attack DNA, causing single-strand or double-strand breaks, activating PARP-1, consuming NAD and ATP, and generating poly(ADP-ribose), resulting in mitochondrial membrane potential loss and the release of apoptosis-inducing factor, ultimately resulting in cell death [252]

For someone starting at 200 lbs, the number approaches 48 lbs