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Moreover, in calves and sheep, when used together with other highly lipophilic anthelmintics, e.g., rafoxanide, the co-administration causes a redistribution of tissues and changes in pharmacokinetic behavior due to competitive lipid partitioning and protein-binding effects (99)

DM is known to damage various regions of the brain, including the hippocampus, cortex, and cerebellum, due to the excessive oxidative stress (do Prado et al., 2020