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The changes in the rating scale scores indicate the presence of moderate depression and anxiety symptoms consistent with major depression and GAD and the presence of a chronic fatigue syndrome (lasting 23 months), including chronic fatigue, insomnia, autonomic and gastro-intestinal symptoms, and, to a lesser extent, cognitive impairments

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A Wnt antagonist, Frzb (also known as SFRP3 ), is expressed on the opposite side of the developing organ of Corti, possibly creating a gradient of active Wnt5a signaling across the sensory domain