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This finding indicates that the lateral rotational movement of the KAR ligand-binding domains is critical for complete channel closure and stabilization of the fully desensitized receptor

With the treatment of protein synthesis inhibitor cycloheximide (CHX) and TGF-1, Sirt2 overexpression (S2OE) promoted the degradation of TGFBR1, but not TGFBR2 (Fig