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Restricting -synuclein transport into mitochondria by inhibition of -synucleinVDAC complexation as a potential therapeutic target for parkinsons disease treatment

The serine-threonine kinase Akt has been reported to down-regulate antioxidant defenses and promote tumor cell survival [166]

[74], transglutaminase (TGase), which is one of the enzymes that is often used, can effectively modify the activity of proteins and enhance cross-linking when used in food systems

Additionally, hypomethylation of the BIN1 gene at specific CpGs (26, 44, and 87) in the blood has been associated with an increased risk of LOAD (Salcedo-Tacuma et al., 2019), while hypermethylation of the PIN1 gene promoter distinguished frontotemporal dementia (FTD) from the hypomethylation observed in AD (Ferri et al., 2016)