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Lead-induced damage to the lining cells of the proximal tubular system results in the formation of nuclear inclusions and ultimately renal glycosuria and aminoaciduria, which are characterized by high levels of sugar and amino acids in the urine, respectively (Kellum et al

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While grain-free diets carry the most documented risk for taurine deficiency, taurine synthesis declines with age in all dogs, and the Columbia University study showed lifespan and cellular aging benefits from supplementation regardless of dietary taurine content