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An increase in respiratory drive elicited by GSGee may decrease the number of sighs and decrease the number of apneas, but that would not be defined definitively by a change in the rejection index since this index also includes sniffs and changes in respiratory waveforms due to behavioral movements 87 , although it must be noted that the fentanyl-treated rats (those that received vehicle or GSHee) were basically immobile throughout the ventilatory study

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In the locus coeruleus of young rats, those opioid peptides produce heterologous MOR desensitization with 2 adrenoreceptors in a GRK2-dependent manner but independently of its kinase activity

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