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Processing methods also warrant optimization: dehulling and milling can dramatically reduce rutin levels (which in common buckwheat seed range from ~ 748 mg per 100 g dry weight, depending on genotype), while fermentation and germination might substantially enhance the bioaccessibility of flavonoids

It is possible that sub-lethal concentrations of mitochondrial inhibitors that do not generate ROS (or generate less ROS) could be beneficial but little is known

This increase is likely linked to the consumption of a high-energy diet, which appears to promote the mRNA expression of the FABP3 and APOB genes, thereby facilitating the increased IMF deposition in muscle tissues [112]