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Cancers (Basel) 12(2):310 Okazaki A, Gameiro PA, Christodoulou D (2017) Glutaminase and poly(ADP-ribose) polymerase inhibitors suppress pyrimidine synthesis and VHL-deficient renal cancers

Continued research into understanding these crossroads is critical for designing combination treatments (that target two or more death modalities) to improve therapeutic outcomes

Nucleation phase Metastable C-terminal truncated Syn variants interact with a plethora of random proteins and membrane-bound organelles in their vicinity within the crowded intracellular environment