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Nevertheless, a subset of patients continues to face therapeutic challenges associated with primary/secondary treatment failure, adverse reactions, and disease heterogeneity, which has driven the development of emerging therapies based on pathological mechanisms

Amiodarone This is an anti-arrhythmic drug that contains iodine, thus delivering a large iodine load to the patient, which may induce a particular type of thyrotoxicosis (see webpage 'Overview' of thyrotoxicosis)